These Italian Beef Sandwiches are a revelation for sandwich night! Featuring an incredibly easy, tender beef roast made effortlessly in your slow cooker, they are served on hearty rolls and elevated by an easy-to-make, zesty Ranch Horseradish sauce. Get ready for a weeknight dinner that feels gourmet.
Calling all sandwich enthusiasts – it’s time to elevate your dinner game! If you’re anything like me, a dedicated sandwich night is a highlight of the week. There’s something inherently satisfying about a perfectly crafted sandwich, especially when it involves tender, slow-cooked meat. For those eager to explore more delightful sandwich creations, be sure to explore our Monte Cristo Sandwiches, this classic Club Sandwich, or these comforting Toasted Cheese Sandwiches. And if you’re craving another Italian-inspired sensation, our Italian Sub is a must-try.

Unlock Effortless Weeknight Dinners with Your Slow Cooker
In the whirlwind of daily life, where time often feels like a precious commodity, the slow cooker emerges as a culinary hero. It’s an indispensable kitchen appliance that consistently delivers flavorful, comforting meals with minimal effort, transforming busy evenings into opportunities for delicious dining. Recently, while sifting through our archives for fresh dinner inspiration, I rediscovered the recipe for these incredible Slow Cooker Italian Beef Sandwiches. I was astonished by how long it had been since they graced our table. Instantly, they were added to the menu, and the rave reviews were so overwhelming that we ended up making them twice in a single month!
The beauty of this slow cooker Italian beef recipe lies in its simplicity and the deep, rich flavors it develops over time. While the beef does require a lengthy cooking period to achieve that fall-apart tender consistency, the active prep time is incredibly short. This makes it an ideal candidate for advanced meal preparation. You can effortlessly assemble all the ingredients the night before (a task that takes mere minutes!), then simply transfer everything to the slow cooker early the next morning. Imagine coming home to the enticing aroma of perfectly cooked beef, ready to be transformed into mouthwatering sandwiches. Alternatively, cook the beef one day and reheat it for dinner the following evening. And for those days when time is truly of the essence, we’ve also included clear instructions below on how to adapt this recipe for the Instant Pot, drastically cutting down on cooking time without compromising on flavor.
The Secret Weapon: Zesty Ranch Horseradish Sauce
What truly sets these Italian Beef Sandwiches apart, transforming them from merely good to absolutely unforgettable, is the vibrant Ranch Horseradish Sauce. As a devoted fan of horseradish, I find myself wanting to generously slather this creamy, tangy, and subtly spicy concoction on nearly everything! This sauce is surprisingly simple to prepare, requiring just a handful of ingredients and minimal effort. Its bold flavor profile perfectly complements the savory, tender beef, creating a harmonious blend that elevates every bite. This sandwich isn’t just a meal; it’s a testament to how simple ingredients, when thoughtfully combined, can create a truly exceptional and weeknight-winning dinner experience.

Key Ingredients for Unforgettable Italian Beef Sandwiches
Crafting the perfect Italian Beef Sandwich begins with selecting the right ingredients. Each component plays a vital role in building the layers of flavor and texture that make this dish so beloved.
- Chuck Roast: The choice of beef cut is paramount for truly tender, shreddable Italian Beef. Chuck roast, with its generous marbling and connective tissues, is the absolute best option. These tissues break down beautifully during the slow cooking process, resulting in incredibly moist and flavorful meat that practically melts in your mouth. While a bottom round roast can be used, it tends to be leaner and may not achieve the same level of tenderness or shreddability as chuck roast.
- Italian Dressing Mix: This convenient packet of dried seasonings is a powerhouse of flavor, instantly infusing the beef with classic Italian herbs and spices. Found typically near salad dressings, it’s a simple shortcut to a complex flavor profile. For those who prefer a homemade approach, you can certainly blend your own Italian seasoning mix using dried oregano, basil, thyme, garlic powder, onion powder, and a pinch of red pepper flakes.
- Onion & Bell Pepper: These aromatic vegetables are more than just fillers; they are essential for building the foundational flavors of the beef. As they slowly cook with the roast, they release their sweet and savory notes, enriching the broth and adding a subtle depth to the overall dish.
- Beef Broth: Beyond simply providing the liquid medium for cooking, beef broth is crucial for imparting a rich, savory essence to the roast. It helps keep the meat moist and tender while creating a flavorful jus that the shredded beef will absorb, ensuring every bite is succulent.
- Pepperoncini Juice: This is our “secret” ingredient, and it’s a game-changer! The tangy, slightly spicy, and briny liquid from a jar of pepperoncini peppers adds an unparalleled layer of complex flavor that brightens the entire dish. Don’t discard the peppers themselves – you’ll use those to garnish your sandwiches, making this a zero-waste flavor booster.
- Sour Cream: Forming the creamy base of our extraordinary Ranch Horseradish Sauce, sour cream provides a delightful tang and smooth texture that balances the horseradish’s bite.
- Ranch Seasoning: For the sauce, we rely on powdered ranch seasoning. This delivers that familiar, herbaceous, and slightly savory ranch flavor effortlessly, complementing the sour cream and horseradish perfectly.
- Horseradish: To achieve the signature zing of our sauce, opt for plain prepared horseradish. It’s important to avoid creamy horseradish or varieties with added ingredients, as these can alter the desired sharp, pungent flavor that makes the sauce so special.
- Rolls: A sturdy roll is essential to stand up to the juicy beef and flavorful sauce. Hoagie rolls are the traditional choice, and while many readily available options work well, seek out a heartier, more substantial roll if possible. A good roll will absorb the juices without becoming soggy.
- Cheese: Sliced provolone cheese is the traditional and highly recommended choice, melting beautifully and adding a mild, creamy counterpoint to the savory beef. However, feel free to customize with your favorite meltable cheese, such as mozzarella or even a sharp cheddar for a different twist.
- Pepperoncini Peppers: These delightful pickled peppers, typically found in a jar, are optional but highly recommended. Their mild heat and tangy crunch provide a fantastic textural and flavor contrast, truly completing the Italian Beef Sandwich experience.

How to Prepare Irresistible Slow Cooker Italian Beef Sandwiches
Creating these tender and flavorful Italian Beef Sandwiches is a straightforward process, primarily thanks to the magic of the slow cooker. Follow these steps for a perfectly cooked roast and an unforgettable meal.
Step 1: Prepare the Roast for Slow Cooking (PHOTO 1)
Begin by placing your chuck roast at the bottom of your slow cooker. For even cooking and maximum flavor infusion, try to arrange it in a single layer if your slow cooker allows. This ensures that all sides of the beef are exposed to the wonderful seasonings and liquids.
Step 2: Add Flavor and Cook (PHOTO 2)
Generously sprinkle the dry Italian seasoning mix over the top of the chuck roast. Next, evenly distribute the chopped onion and green bell pepper around and over the beef. Pour in the beef broth and, crucially, the pepperoncini juice. The pepperoncini juice adds a distinctive tangy and slightly spicy kick that is essential to the Italian beef flavor profile. Once all ingredients are in, securely place the lid on your slow cooker. Cook the roast on the low setting until it is incredibly tender and can be easily shredded with a fork. This typically takes anywhere from 10 to 12 hours. Keep in mind that slow cooker temperatures can vary, so monitor your roast for optimal tenderness.

Step 3: Prepare the Ranch Horseradish Sauce (PHOTO 3)
While your beef roast is slowly cooking to perfection, take a few minutes to prepare the star sauce. In a small bowl, combine the sour cream, dry ranch seasoning mix, and the prepared horseradish. Whisk everything together until it’s smooth and well-combined. Cover the bowl and refrigerate the sauce. This allows the flavors to meld and deepen, creating a more cohesive and delicious sauce that will perfectly complement your sandwiches.
Step 4: Shred the Beef (PHOTO 4)
Once the roast is thoroughly cooked and wonderfully tender, carefully remove it from the slow cooker and transfer it to a cutting board. Using two forks, begin to shred the beef into bite-sized pieces. It should pull apart very easily if cooked correctly. After shredding, return all the tender beef back into the slow cooker, allowing it to soak up all the flavorful cooking juices. This step is crucial for ensuring the beef remains moist and infused with all the wonderful flavors.

Step 5: Assemble the Sandwiches (PHOTO 5)
Preheat your oven’s broiler. Take each hoagie roll and spread a generous amount of the prepared Ranch Horseradish sauce onto both halves. We find that applying the sauce to both sides enhances the flavor experience, but you can certainly apply it to just one half if you prefer. Then, pile a hearty portion of the shredded Italian beef onto the bottom half of each bun. Top the beef with some sliced pepperoncini peppers for that extra tangy crunch.
Step 6: Melt the Cheese and Serve (PHOTO 6)
Carefully place slices of provolone cheese over the pepperoncini peppers and beef. Tear the cheese as needed to ensure good coverage. Transfer the assembled open-faced sandwiches to a baking sheet and place them under the preheated broiler. Watch them closely, broiling just until the cheese is perfectly melted and bubbly, about 1-2 minutes. Once the cheese is melted, remove them from the oven, place the top bun on each sandwich, and serve immediately to enjoy this warm, cheesy, and tender Italian beef delight.

Instant Pot vs. Slow Cooker: A Time-Saving Alternative
While the slow cooker excels at developing deep flavors over a long period, sometimes you just need dinner on the table faster. If you’re looking to significantly reduce the cooking time for this Italian Beef recipe without sacrificing tenderness or flavor, your Instant Pot is the perfect tool. Here’s how to adapt the recipe for pressure cooking:
- Prepare the Beef: To ensure faster cooking and even tenderness, cut your chuck roast into 4-6 more manageable pieces. Place these beef pieces directly into the inner pot of your Instant Pot.
- Add Seasonings and Aromatics: Sprinkle the Italian seasoning mix, chopped onions, and bell peppers over the beef. Stir gently to ensure the seasonings are distributed.
- Introduce Liquids: Pour the beef broth and, importantly, the pepperoncini juice over the seasoned beef and vegetables. Give it another light stir to combine.
- Set the Pressure Cooker: Secure the lid on your Instant Pot, making sure it is properly locked into place. Crucially, confirm that the vent is sealed (usually set to the “Sealing” position, not “Venting”).
- Cook under Pressure: Select the “Manual” or “Pressure Cook” setting on your Instant Pot and set the cooking time for 60 minutes. This high-pressure cooking will tenderize the beef rapidly.
- Natural Release: Once the cooking cycle is complete, allow the Instant Pot to naturally release pressure for 10 minutes. This natural release period is important for allowing the beef to rest and retain its juices, contributing to its tenderness. After 10 minutes, carefully switch the vent to the “Venting” position to quick-release any remaining pressure.
- Shred and Serve: Once the pressure has fully released, open the lid. Remove the beef and shred it using two forks, then return it to the flavorful juices in the Instant Pot. From this point, you can proceed with assembling your Italian Beef Sandwiches as outlined in the slow cooker recipe instructions, including preparing the Ranch Horseradish sauce and broiling with cheese.

Tips for the Best Italian Beef Sandwiches
- Quality Meat: Don’t skimp on the chuck roast. A well-marbled piece will yield the most tender and flavorful results.
- Don’t Rush the Cook: For slow cooker method, resist the urge to open the lid too often. Each time you lift it, heat escapes and prolongs the cooking time.
- Chill the Sauce: Allowing the Ranch Horseradish sauce to chill for at least 30 minutes lets the flavors fully develop and meld.
- Hearty Rolls are Key: A flimsy bun will quickly fall apart under the juicy beef. Choose a robust hoagie or sub roll that can hold up to the moisture and fillings.
- Toasting the Buns: While not explicitly in the steps, a lightly toasted bun (before adding fillings) can add a nice texture and prevent immediate sogginess.
- Serving Suggestions: These sandwiches are fantastic on their own, but pair them with a simple green salad, some crispy potato chips, or a side of creamy coleslaw for a complete meal.
Whether you opt for the slow cooker’s leisurely pace or the Instant Pot’s rapid results, these Italian Beef Sandwiches promise a deeply satisfying and flavor-packed meal that will undoubtedly become a regular in your rotation. The combination of tender, savory beef, tangy peppers, and the distinctive Ranch Horseradish sauce is truly a match made in culinary heaven.
More Delicious Slow Cooker Recipes to Simplify Your Life
Embrace the convenience and incredible flavor that slow cooking brings to your kitchen. Here are some more of our favorite slow cooker recipes that are perfect for busy days and comforting meals:
Classic Crock Pot Chili
Flavorful Crockpot BBQ Pulled Chicken
Simple Slow Cooker Black Beans
Hearty Slow Cooker Cuban Ropa Vieja
Creamy Slow Cooker Spinach Artichoke Dip
LOOKING FOR MORE FREE RECIPES?
Subscribe to my free recipe newsletter to get new family-friendly recipes delivered directly to your inbox each week! Find me sharing even more culinary inspiration and family meal ideas on Pinterest, Facebook, and Instagram.

Italian Beef Sandwiches
Pin Recipe
Ingredients
- 2-3 lb beef chuck roast
- 0.7 oz package dry Italian dressing mix
- 1 cup chopped onion
- 1 cup chopped green bell pepper
- 1 cup beef broth
- 1/2 cup pepperoncini juice
- 1/2 cup sour cream
- 1 teaspoon dry ranch dressing mix
- 1 teaspoon horseradish
- 8 Hoagie rolls
- 8 oz sliced provolone cheese
- Pepperoncini peppers or banana peppers (for serving)
Instructions
- Place the chuck roast in a large slow cooker. Sprinkle the Italian seasoning mix over the top, then add the onion and bell pepper. Pour the beef broth and the pepperoncini juice over the top, cover, and cook on low for 10-12 hours, or until the beef easily shreds.
- While the beef is cooking, mix the sour cream, ranch seasoning mix, and horseradish together. Cover and refrigerate to allow flavors to meld.
- When the beef is done, remove from the slow cooker to a cutting board and shred. Return the shredded beef to the slow cooker to combine with the juices.
- Turn the oven on to broil. Spread the bun with the ranch horseradish sauce (you can add it to just one side of the sandwich, but we like to add it to both sides!). Top with some of the shredded beef, add sliced pepperoncini peppers, then cover with cheese. Place under the broiler just until the cheese melts.
- Place the top bun on top and serve immediately.
